Pyridinium chloride → HCID 66933987, compound

HRID 1363401Notes

Reaction equation

HRID 1363401 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([O:19]C)[CH:13]=[C:12]([O:21]C)[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])=[C:4]([Br:31])[CH:3]=1.Cl.N1C=CC=CC=1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([OH:19])[CH:13]=[C:12]([OH:21])[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])=[C:4]([Br:31])[CH:3]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 66933619HCID 66933619, compound

Product 1

HCID 66933987HCID 66933987, compound

Procedure

Compound of example 146 (0.150 g, 0.3 mmol) was demethylated using pyridine hydrochloride (1.5 g, 13 mmol) as described in example 17 to obtain the title compound.

Sources & evidence

ORD record
ord-aa561f36168f49f7bc2c02416b1cd659
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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