反应详情

2-Chloro-5-nitrobenzoic acid (11 g, 54.5 mmol) was dissolved in methanol (100 mL). Conc. H2SO4 (2 mL) was added slowly and the reaction mixture heated to reflux for 4 h. The mixture was concentrated and the residue was allowed to cool to room temperature. It was poured over crushed ice. The organic product was extracted using diethyl ether (2×200 mL). The organic extract was washed with water, 10% aqueous NaHCO3, dried (anhydrous Na2SO4) and concentrated to get the title compound.

1. temperaturethe reaction mixture heated
2. temperatureto reflux for 4 h
3. concentrationThe mixture was concentrated
4. additionIt was poured
5. customover crushed ice
6. extractionThe organic product was extracted
7. extractionThe organic extract
8. washwas washed with water, 10% aqueous NaHCO3
9. dry with materialdried (anhydrous Na2SO4)
10. concentrationconcentrated