Methyl 4-Amino-2-chlorobenzoate → 2-Chloro-4-hydroxy-benzoic acid methyl ester

Participants

Reaction Steps

Compound of example 162 (7.9 g, 42.5 mmol) suspended in 10% aqueous H2SO4 (80 mL) was reacted with NaNO2 (3.5 g, 52.1 mmol in 35 mL water) as described in example 174. It was treated with a solution of CuSO4.5H2O (128 g, 513 mmol) and Cu2O (5.5 g, 38.4 mmol) in water (800 mL) as described in the same procedure to obtain the title compound.

Provenance & Evidence