反应详情

2-Bromo-4-nitro-benzonitrile (0.5 g, 2.34 mmol) was hydrolysed using H2SO4 (2.2 mL) in water (2.7 mL) at 80° C. for 8 h. After completion of reaction, the solution was poured over crushed ice, basified with sodium carbonate and extracted with EtOAc. Aqueous layer was separated, acidified with 1:1 HCl and extracted with EtOAc (3×100 mL). The combined organic layers were concentrated to obtained compound.

1. customat 80° C.
2. customfor 8 h
3. customAfter completion of reaction
4. additionthe solution was poured
5. customover crushed ice
6. extractionextracted with EtOAc
7. customAqueous layer was separated
8. extractionextracted with EtOAc (3×100 mL)
9. concentrationThe combined organic layers were concentrated
10. customto obtained compound