2-Chloro-6-methylbenzoic acid → HCID 58915113, compound

HRID 1363466Notes

Reaction equation

[NH2:1][C@@H:2]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15](=[O:27])[N:16]([CH3:26])[C:17]3[C:22]([C:23]=2[O:24][CH3:25])=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:10][CH:9]=1)[C:3]([O:5][CH3:6])=[O:4].[Cl:28][C:29]1[CH:37]=[CH:36][CH:35]=[C:34]([CH3:38])[C:30]=1[C:31](O)=[O:32]>>[Cl:28][C:29]1[CH:37]=[CH:36][CH:35]=[C:34]([CH3:38])[C:30]=1[C:31]([NH:1][C@@H:2]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15](=[O:27])[N:16]([CH3:26])[C:17]3[C:22]([C:23]=2[O:24][CH3:25])=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:10][CH:9]=1)[C:3]([O:5][CH3:6])=[O:4])=[O:32]

Participants

Reactant 2

HCID 888702-Chloro-6-methylbenzoic acid

HCID 58915078HCID 58915078, compound

Product 1

HCID 58915113HCID 58915113, compound

Procedure

The compound obtained as an intermediate in Process 3 of Example 6, that is, methyl (2S)-2-amino-3-[4-(4-methoxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)phenyl]propionate (50 mg) was acylated with 2-chloro-6-methylbenzoic acid by the same procedure as that of Process 1 of Example 17 to obtain methyl (2S)-2-[(2-chloro-6-methylbenzoyl)amino]-3-[4-(4-methoxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)phenyl]propionate (38 mg).

Workup

customThe compound obtained as an intermediate in Process 3 of Example 6

Sources & evidence

ORD record: ord-3764c6a9988c4087b819542a2dd15b81
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07884204B2

Reaction notes

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