Carbon Tetrachloride → 3-Bromo-6-chloroquinoline

Participants

Reaction Conditions

Reaction Steps

The synthesis was done by the same procedure as that of J. J. Eisch (J. Org. Chem. Vol. 27, p. 1318, 1962). Bromine (79 μl) and carbon tetrachloride (2 ml) were added to 6-chloroquinoline (250 mg) and stirred at 90° C. for two hours. Pyridine (123 μl) was added to the reaction solution and stirred at the same temperature for 16 hours. The reaction solution was concentrated and purified with a silica gel chromatography (hexane-ethyl acetate) to obtain the title compound (250 mg).

Provenance & Evidence