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HRID1363567

反应详情

EQUATION

反应方程式

HRID 1363567 的结构方程式

REACTANTS

反应物

2
结构：CCOCc1nc2cnc3ccccc3c2n1CC1(O)CCN(C(C)=O)CC1
HCID57515413

未命名化合物

结构：CCOCc1nc2cnc3ccccc3c2n1CC1(OCCS(C)(=O)=O)CCN(C(C)=O)CC1
HCID57515414

未命名化合物

PRODUCTS

生成物

1
结构：CCOCCc1nc2cnc3ccccc3c2n1CC1(OCCS(C)(=O)=O)CCN(C(C)=O)CC1
HCID57515415

未命名化合物

收率 13%

PROCEDURE

实验过程

1-Acetyl-4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}piperidin-4-ol (1.80 g, 4.68 mmol) was converted into 1-({1-acetyl-4-[2-(methylsulfonyl)ethoxy]piperidin-4-yl}methyl)-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinoline according to the method described in Part A of Example 13. Purification by flash chromatography (silica gel, eluted with 10% methanol/dichloromethane) yielded 1-({1-acetyl-4-[2-(methylsulfonyl)ethoxy]piperidin-4-yl}methyl)-2-(ethoxyethyl)-1H-imidazo[4,5-c]quinoline (0.30 g, 13%) and recovered starting material, 1-acetyl-4-{[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]methyl}piperidin-4-ol (1.20 g).

WORKUP

后处理

  1. customPurification
  2. washby flash chromatography (silica gel, eluted with 10% methanol/dichloromethane)