Sodium Hydroxide → HCID 24953032, compound

HRID 1363649Notes

Reaction equation

HRID 1363649 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([CH3:32])[CH:31]=1)[CH2:5][N:6]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)[C:7](=[O:11])[C:8]([O-:10])=[O:9].[OH-].[Na+:34]>O>[Na+:34].[CH3:32][C:30]1[CH:29]=[C:4]([CH:3]=[C:2]([CH3:1])[CH:31]=1)[CH2:5][N:6]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:26])([F:27])[F:28])=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)[C:7](=[O:11])[C:8]([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131728691HCID 131728691, compound

Product 1

HCID 24953032HCID 24953032, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

N-(3,5-dimethylbenzyl)-N-[4′-(trifluoromethoxy)biphenyl-4-yl]oxamate (200 mg, 0.437 mmol), 2N aqueous sodium hydroxide (2 ml) and water (1 ml) was irradiated with ultrasound for 5 minutes. The reaction mixture was diluted with water, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (130 mg, 66%) as a white solid.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5233283a7bce4fd39f6bb4cbda7dff4c
Source dataset
uspto-grants-2011_02
Patent number
US07884234B2

Reaction notes

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