Phenethylamine → N-Cyclohexyl-p-ethoxyaniline

Participants

Reaction Steps

Phenethylamine (121 mg, 1.0 mmol) in a 2:1 mixture of THF-MeOH (2 mL) was added cyclohexanone (98 mg, 1.0 mmol) and molecular sieves (4 Å, 80 mg). The reaction mixture was shaken for 1 h before NaBH3CN (126 mg, 2.0 mmol) was added. The reaction mixture was shaken for 24 h before it was filtered and the filtrate was concentrated in vacuo to give the intermediate cyclohexyl phenetylamine.

Provenance & Evidence