3-Methylbutanal → HCID 57668351, compound

HRID 1363719Notes

Reaction equation

HRID 1363719 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=CC=C[CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:29](=[O:34])[CH2:30][CH:31](C)C.C(O[C@H]1CC[C@H](N)CC1)CC.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:28][CH:23]([CH3:24])[CH2:22][CH2:21][N:7]([CH:1]1[CH2:2][CH2:3][CH:4]([O:34][CH2:29][CH2:30][CH3:31])[CH2:5][CH2:6]1)[C:8](=[O:20])[NH:9][C:10]1[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=1

Participants

5

Reactant 4

HCID 115523-MethylbutanalHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178459267HCID 178459267, compound

Product 1

HCID 57668351HCID 57668351, compound

Procedure

{2-[3-(3-Methyl-butyl)-3-(4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid was prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid using isovaleraldehyde, trans-4-propoxy-cyclohexylamine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-de238295544f4a6a8fbcb74cd2bb016e
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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