3-Methylbutanal → HCID 178467889, compound

HRID 1363724Notes

Reaction equation

HRID 1363724 reaction equation
[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=CC=C[CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)CC(C)C.[CH2:35]([O:37][CH2:38][C@H]1CC[C@H](N)CC1)[CH3:36].COCC1CCC(N(CCC(C)C)C(=O)NC2SC(SCC(O)=O)=CN=2)CC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH2:35]([O:37][CH2:38][C@H:4]1[CH2:3][CH2:2][C@H:1]([N:7]([CH2:21][CH2:22][CH:23]([CH3:24])[CH3:28])[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][N:14]=2)[CH2:6][CH2:5]1)[CH3:36]

Participants

6

Reactant 5

HCID 115523-MethylbutanalHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668200HCID 57668200, compoundHCID 178467888HCID 178467888, compound

Product 1

HCID 178467889HCID 178467889, compound

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid using isovaleraldehyde, trans-4-ethoxymethyl-cyclohexylamine (prepared in accordance with the general method given for the preparation of {2-[3-(4-methoxymethyl-cyclohexyl)-3-(3-methyl-butyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid) and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Workup

  1. customPrepared
  2. customprepared in accordance with the general method

Sources & evidence

ORD record
ord-100846db57c04c24959a8c9085868199
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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