3-Methylbutanal → HCID 178446664, compound

HRID 1363725Notes

Reaction equation

HRID 1363725 reaction equation
C1(N(C[CH2:22][C:23]2[CH:28]=CC=CC=2)C(=O)NC2SC(SCC(O)=O)=CN=2)CCCCC1.C(=O)CC(C)C.C1([C@H]2CC[C@H](NCOC)CC2)CC1.[CH3:48][O:49][CH2:50][CH:51]1[CH2:56][CH2:55][CH:54]([N:57]([CH2:71][CH2:72][CH:73]([CH3:75])[CH3:74])[C:58](=[O:70])[NH:59][C:60]2[S:61][C:62]([S:65][CH2:66][C:67]([OH:69])=[O:68])=[CH:63][N:64]=2)[CH2:53][CH2:52]1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH:28]1([CH2:48][O:49][CH2:50][C@H:51]2[CH2:56][CH2:55][C@H:54]([N:57]([CH2:71][CH2:72][CH:73]([CH3:75])[CH3:74])[C:58](=[O:70])[NH:59][C:60]3[S:61][C:62]([S:65][CH2:66][C:67]([OH:69])=[O:68])=[CH:63][N:64]=3)[CH2:53][CH2:52]2)[CH2:23][CH2:22]1

Participants

6

Reactant 5

HCID 115523-MethylbutanalHCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668200HCID 57668200, compoundHCID 178496793HCID 178496793, compound

Product 1

HCID 178446664HCID 178446664, compound

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid using isovaleraldehyde, trans-4-cyclopropyl-methoxymethyl-cyclohexylamine (prepared in accordance with the general method given for the preparation of {2-[3-(4-methoxymethyl-cyclohexyl)-3-(3-methyl-butyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid) and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester.

Workup

  1. customPrepared
  2. customprepared in accordance with the general method

Sources & evidence

ORD record
ord-bc55b2320718419d98ec2a35ac43d958
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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