{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acid → HCID 57668317, compound

HRID 1363761Notes

Reaction equation

HRID 1363761 reaction equation
C(OC(=O)C([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([CH2:27][CH:28]2[CH2:32][CH2:31][CH2:30][CH2:29]2)[C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23](=[O:26])[NH:24][CH3:25])[CH:18]=2)=[O:15])=[N:10][CH:9]=1)C)C.C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=[C:46]([CH2:48][C:49]([OH:51])=[O:50])N=2)CCCC1.C1(CNC2C=C(C=CC=2)C(NC)=O)CCCC1.C(OC(=O)C(SC1SC(N)=NC=1)C)C>>[CH:28]1([CH2:27][N:16]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23](=[O:26])[NH:24][CH3:25])[CH:18]=2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:46][CH2:48][C:49]([OH:51])=[O:50])=[CH:9][N:10]=2)[CH2:32][CH2:31][CH2:30][CH2:29]1

Participants

5

Reactant 4

HCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 620720763-[(Cyclopentylmethyl)amino]-N-methylbenzamideHCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 86629894HCID 86629894, compound

Product 1

HCID 57668317HCID 57668317, compound

Procedure

The title compound was prepared via {2-[3-cyclopentylmethyl-3-(3-methylcarbamoyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using 3-(cyclopentylmethyl-amino)-N-methyl-benzamide and (2-amino-thiazol-5-ylsulfanyl) propionic acid ethyl ester

Sources & evidence

ORD record
ord-3b08617904154065bcb4415d40c46e39
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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