Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668441, compound

HRID 1363784Notes

Reaction equation

HRID 1363784 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([N:30]3[CH2:33][CH2:32][CH2:31]3)=[O:29])[CH:23]=2)[CH2:16][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:14])=[N:9][CH:8]=1)C.C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.N1(C(C2C=CC=C(NCC3CCCC3)C=2)=O)CCC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[N:30]1([C:28]([C:24]2[CH:23]=[C:22]([N:15]([CH2:16][CH:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[C:13](=[O:14])[NH:12][C:10]3[S:11][C:7]([S:6][CH2:5][C:4]([OH:34])=[O:3])=[CH:8][N:9]=3)[CH:27]=[CH:26][CH:25]=2)=[O:29])[CH2:31][CH2:32][CH2:33]1

Participants

5

Reactant 4

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 66961954(Azetidin-1-yl){3-[(cyclopentylmethyl)amino]phenyl}methanoneHCID 86629917HCID 86629917, compound

Product 1

HCID 57668441HCID 57668441, compound

Procedure

The title compound was prepared via (2-{3-[3-(azetidine-1-carbonyl)-phenyl]-3-cyclopentylmethyl-ureido}-thiazol-5-ylsulfanyl)-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using azetidin-1-yl-[3-(cyclopentylmethyl-amino)-phenyl]-methanone and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.

Sources & evidence

ORD record
ord-918f3f6e6bfa4747b8ecdf88ef8edb78
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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