Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668341, compound

HRID 1363787Notes

Reaction equation

HRID 1363787 reaction equation
C([O:3][C:4](=[O:35])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[C:29]([F:34])[CH:28]=2)[CH2:16][CH:17]2[CH2:22][CH2:21][CH:20]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:19][CH2:18]2)=[O:14])=[N:9][CH:8]=1)C.C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.C(C1CCC(CNC2C=CC(F)=C(F)C=2)CC1)(C)(C)C.C(OC(=O)CSC1SC(N)=NC=1)C>>[C:23]([CH:20]1[CH2:21][CH2:22][CH:17]([CH2:16][N:15]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[C:29]([F:34])[CH:28]=2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:35])=[O:3])=[CH:8][N:9]=2)[CH2:18][CH2:19]1)([CH3:26])([CH3:24])[CH3:25]

Participants

5

Reactant 4

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 66961992N-[(4-tert-Butylcyclohexyl)methyl]-3,4-difluoroanilineHCID 86629920HCID 86629920, compound

Product 1

HCID 57668341HCID 57668341, compound

Procedure

The title compound was prepared via {2-[3-(3,4-difluoro-phenyl)-3-(4-tert-butyl-cyclohexylmethyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using 4-tert-butyl-cyclohexylmethyl-(3,4-difluorophenyl)-amine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.

Sources & evidence

ORD record
ord-4cbd698de4e44b6f87beb2696e516c61
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

Loading…