Acetamide, N-[3-[(phenylmethyl)amino]phenyl]- → HCID 57668326, compound

HRID 1363793Notes

Reaction equation

HRID 1363793 reaction equation
C([O:3][C:4](=[O:33])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:30](=[O:32])[CH3:31])[CH:24]=2)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])=[N:9][CH:8]=1)C.C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.C(NC1C=C(NCC2C=CC=CC=2)C=CC=1)(=O)C.C(OC(=O)CSC1SC(N)=NC=1)C>>[C:30]([NH:29][C:25]1[CH:24]=[C:23]([N:15]([CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:33])=[O:3])=[CH:8][N:9]=2)[CH:28]=[CH:27][CH:26]=1)(=[O:32])[CH3:31]

Participants

5

Reactant 4

HCID 120134Acetamide, N-[3-[(phenylmethyl)amino]phenyl]-HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 86629926HCID 86629926, compound

Product 1

HCID 57668326HCID 57668326, compound

Procedure

The title compound was prepared via {2-[3-(3-acetylamino-phenyl)-3-benzyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using (3-acetylamino-phenyl)-benzylamine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.

Sources & evidence

ORD record
ord-8ec020ac95b24cfba6901d908460e093
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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