Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668288, compound

HRID 1363794Notes

Reaction equation

HRID 1363794 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([NH:30][C:31](=[O:33])[CH3:32])[CH:25]=2)[CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:14])=[N:9][CH:8]=1)C.C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.C(NC1C=C(NCCC2C=CC=CC=2)C=CC=1)(=O)C.C(OC(=O)CSC1SC(N)=NC=1)C>>[C:31]([NH:30][C:26]1[CH:25]=[C:24]([N:15]([CH2:16][CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:34])=[O:3])=[CH:8][N:9]=2)[CH:29]=[CH:28][CH:27]=1)(=[O:33])[CH3:32]

Participants

5

Reactant 4

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 28453152HCID 28453152, compoundHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 86629927HCID 86629927, compound

Product 1

HCID 57668288HCID 57668288, compound

Procedure

The title compound was prepared via {2-[3-(3-acetylamino-phenyl)-3-phenethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using (3-acetylamino-phenyl)-phenethylamine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.

Sources & evidence

ORD record
ord-39f4ef7d45504eea82f268912d032bda
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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