Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668257, compound

HRID 1363818Notes

Reaction equation

HRID 1363818 reaction equation
[CH:1]1([CH2:6][N:7]([C:20]2[CH:25]=[CH:24][C:23](S(C)(=O)=O)=[CH:22][CH:21]=2)[C:8](=[O:19])[NH:9][C:10]2[S:11][CH:12]=[C:13](CC(O)=O)[N:14]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C1(CNC2C=CC=C([Br:43])C=2)CCCC1.C([O:46][C:47](=[O:56])[CH2:48][S:49]C1SC(N)=NC=1)C>>[Br:43][C:22]1[CH:21]=[C:20]([N:7]([CH2:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8](=[O:19])[NH:9][C:10]2[S:11][C:12]([S:49][CH2:48][C:47]([OH:46])=[O:56])=[CH:13][N:14]=2)[CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 613449923-Bromo-N-(cyclopentylmethyl)aniline

Product 1

HCID 57668257HCID 57668257, compound

Procedure

The title compound was prepared via {2-[3-(3-bromo-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl esterin a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentylmethyl-(3-bromo-phenyl)-amine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester

Sources & evidence

ORD record
ord-a0ea4a84aa164bca86c23ad8cc2f5d88
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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