Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668201, compound

HRID 1363821Notes

Reaction equation

HRID 1363821 reaction equation
C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)[C:8](=[O:19])[NH:9][C:10]2[S:11][CH:12]=[C:13](CC(O)=O)[N:14]=2)CCCC1.[CH:30]1([CH2:35][NH:36][C:37]2[CH:42]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:40]=[C:39]([O:47][CH3:48])[CH:38]=2)[CH2:34][CH2:33][CH2:32][CH2:31]1.C([O:51][C:52](=[O:61])[CH2:53][S:54]C1SC(N)=NC=1)C>>[CH:30]1([CH2:35][N:36]([C:37]2[CH:42]=[C:41]([C:43]([F:45])([F:46])[F:44])[CH:40]=[C:39]([O:47][CH3:48])[CH:38]=2)[C:8](=[O:19])[NH:9][C:10]2[S:11][C:12]([S:54][CH2:53][C:52]([OH:61])=[O:51])=[CH:13][N:14]=2)[CH2:31][CH2:32][CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 66962183N-(Cyclopentylmethyl)-3-methoxy-5-(trifluoromethyl)aniline

Product 1

HCID 57668201HCID 57668201, compound

Procedure

The title compound was prepared via {2-[3-(3-methoxy-5-trifluoromethyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl esterin a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentylmethyl-(3-methoxy-5-trifluoromethyl-phenyl)-amine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester

Sources & evidence

ORD record
ord-6e278de05a5d4f4f9166137512a778c0
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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