Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57668220, compound

HRID 1363822Notes

Reaction equation

HRID 1363822 reaction equation
[CH:1]1([CH2:6][N:7]([C:20]2[CH:25]=[CH:24][C:23](S(C)(=O)=O)=[CH:22][CH:21]=2)[C:8](=[O:19])[NH:9][C:10]2[S:11][CH:12]=[C:13](CC(O)=O)[N:14]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C1(CNC2C=CC=[C:39]([C:43](=[O:45])C)C=2)CCCC1.C([O:48][C:49](=[O:58])[CH2:50][S:51]C1SC(N)=NC=1)C>>[C:43]([C:24]1[CH:25]=[C:20]([N:7]([CH2:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8](=[O:19])[NH:9][C:10]2[S:11][C:12]([S:51][CH2:50][C:49]([OH:48])=[O:58])=[CH:13][N:14]=2)[CH:21]=[CH:22][CH:23]=1)(=[O:45])[CH3:39]

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 669619281-{3-[(Cyclopentylmethyl)amino]phenyl}ethan-1-one

Product 1

HCID 57668220HCID 57668220, compound

Procedure

The title compound was prepared via {2-[3-(3-acetyl-phenyl)-3-cyclopentylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl esterin a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentylmethyl-(3-acetyl-phenyl)-amine and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester

Sources & evidence

ORD record
ord-e91d8afe4b764940abbdd2ef4fee6717
Source dataset
uspto-grants-2011_02
Patent number
US07884210B2

Reaction notes

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