Trityl chloride → HCID 59827592, compound

Participants

Reaction Steps

Compound 12 (2.14 g, 10.5 mmol) was dissolved in dry CH2Cl2 (60 ml), in the presence of dry triethylamine (5.9 ml, 42.3 mmol). The solution was cooled (0° C.) and triphenylmethyl chloride (2.94 g, 10.6 mmol) in dry CH2Cl2 (10 ml) was added drop-wise. Once the addition was complete the reaction was warmed to room temperature and stirred for 16 h. The reaction mixture was washed with saturated NaHCO3 (75 mL), water (75 mL), and brine (75 mL). The organic portion was dried (K2CO3), and concentrated in vacuo to give 13 as an amorphous foam (3.96 g, 99% yield). 1H NMR (400 MHz, CDCl3): δ 1.3 (m, 3H), 1.9 (s, 3H), 3.0 (m, 3H), 3.2 (m, 1H), 3.3 (s, 3H), 7.16 (m, 4H), 7.27 (m, 7H), 7.49 (m, 4H).

Provenance & Evidence