Hydrochloric Acid → 11-(3,5-Bis(trifluoromethyl) phenoxy)dodecanoic acid

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Reaction Steps

3,5-Bis(trifluoromethyl) phenol (20.6 g) was dissolved in 1N sodium hydroxide (270 mL). The solution was refluxed under heating for 10 hours. After addition of 11-bromododecanoic acid (4.7 g), the solution was kept refluxed under heating, and then left to be cooled. The reaction solution was added with 1N aqueous hydrochloric acid and extracted with ethyl acetate. The resulting organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed. The resulting crystals was washed with hexane and purified by silica gel column chromatography to obtain 11-(3,5-bis(trifluoromethyl) phenoxy)dodecanoic acid (18.4 g, 50%).

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