反应详情

温度

0 °C

Methyl 9-hydroxynonanoate and pyridine were added to dichloromethane. The solution was stirred at 0° C., added with methanesulfonyl chloride, and further stirred with gradually warming up to room temperature. The solution was added with water, and extracted twice with dichloromethane. The resulting organic layer was washed with 1N hydrochloric acid and saturated sodium hydrogen carbonate. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed and the residue was purified by silica gel column chromatography to obtain methyl 9-(methanesulfonyloxy)nonanoate.

1. stirringfurther stirred
2. temperaturewith gradually warming up to room temperature
3. extractionextracted twice with dichloromethane
4. washThe resulting organic layer was washed with 1N hydrochloric acid and saturated sodium hydrogen carbonate
5. dry with materialAfter the organic layer was dried over anhydrous sodium sulfate
6. customthe solvent was removed
7. customthe residue was purified by silica gel column chromatography