HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Alanine → Pyruvate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Alanine | HCID 71080 | — |
| Reactant | Pyruvate | HCID 107735 | — |
| Reactant | 3-(1H-Indol-3-yl)-2-oxopropanoate | HCID 5460337 | — |
| Reactant | 2-Methylpiperazine, (R)- | HCID 7330434 | — |
| Product | Pyruvate | HCID 107735 | — |
| Product | Monatin | HCID 9860847 | — |
Reaction Steps
In a specific embodiment, L-tryptophan is converted to D-tryptophan using a tryptophan racemase. D-tryptophan then reacts with pyruvate via a broad specificity D-aminotransferase to produce indole-3-pyruvate and D-alanine. Indole-3-pyruvate then reacts with an R-specific aldolase and pyruvate to form R-α-keto acid monatin (R-MP). R-MP then reacts with a broad specificity D-aminotransferase and D-alanine to produce R,R monatin and pyruvate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07888081B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-d27c9508ea0f45159b7e04dbaf5d9ed4 |
| Source note | uspto-grants-2011_02 |