HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1363936Generated: October 25, 2026
hydroxylamine-O-sulfonic acid → 3-Bromo-6-chloro-2-fluorobenzonitrile
https://huagongshe.com/reaction/1363936
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | hydroxylamine-O-sulfonic acid | HCID 76284 | — |
| Reactant | 3-Bromo-6-chloro-2-fluorobenzaldehyde | HCID 59299457 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Bromo-6-chloro-2-fluorobenzonitrile | HCID 50997949 | 100% |
Reaction Steps
A suspension of 3-bromo-6-chloro-2-fluorobenzaldehyde (9.0 g, 0.04 mol) and hydroxylamine-O-sulfonic acid (7.50 g, 0.07 mole) in water (300 mL) was heated at 50° C. for eighteen hours. The suspension was cooled and the solid was collected to give 3-bromo-6-chloro-2-fluorobenzonitrile (8.8 g, 0.04 mol): 1H NMR (CDCl3): δ 7.75 (m, 1H), 7.25 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07888287B2 |
|---|
| Source dataset | uspto-grants-2011_02 |
|---|
| ORD ID | ord-d872e9f2fe4b414ab0fdbb220cd19ce3 |
|---|
| Source note | uspto-grants-2011_02 |
|---|
