HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodoadenosine → 2-{3-[1-((4-Fluorophenoxy)carbonyl)piperidin-4-yl]propyn-1-yl}adenosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodoadenosine | HCID 169662 | — |
| Reactant | 4-Fluorophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate | HCID 57838902 | — |
| Product | 2-{3-[1-((4-Fluorophenoxy)carbonyl)piperidin-4-yl]propyn-1-yl}adenosine | HCID 25094143 | — |
Reaction Steps
Batch: AB-9-147. 4-fluorophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate, batch JR28-97 (0.700 g, 2.68 mmol) was added to a solution of 2-iodoadenosine (0.812 g, 2.065 mmol) according to general procedure 2. Yield: 0.902 g, 83%. 1H NMR (CD3OD) δ 8.34 (s, 1H), 7.11 (m, 4H), 5.98 (d, 1H), 4.76 (m, 2H), 4.37-4.19 (2×m, 3H), 3.95-3.75 (2×d, 2H), 3.07-2.93 (2×bt, 4H), 2.47 (d, 5H), 1.98-1.44 (2×m, 5H). m/z MH+=527.19. HPLC rt=7.6 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07888329B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-de29f77b814c443d9b50ba349867277a |
| Source note | uspto-grants-2011_02 |