Water → HCID 66936679, compound

Participants

Reaction Steps

To a solution of 5-(1,4-dioxa-dispiro[4.1.4.3]tetradec-9-yl)-2-methyl-pentan-2-ol (28′) (290 mg, 0.97 mmol) in acetone (6 mL) was added H2O (catalytic amount) and p-toluenesulfonic acid (catalytic amount). The reaction mixture is stirred at room temperature overnight and then dried over anhydrous MgSO4. The solution is filtered through silica and the filtrate concentrated under reduced pressure. The resulting residue is purified over silica (isooctane/EtOAc, 7:3) to afford the desired product as a colorless oil which was characterized as follows:

Provenance & Evidence