Tetrahydrofuran → HCID 66936807, compound

Participants

Reaction Steps

To a solution of 2-(4-hydroxy-4-methylpentyl)-spiro[4.5]decan-7-one (29′) (100 mg, 0.396 mmol) in dry THF (2 mL) is added 1-(trimethylsilyl)imidazole (0.292 mL, 1.98 mmol). The reaction mixture is stirred at room temperature for 4 hours and the solvent removed in vacuo. The resulting residue is purified over silica (petroleum ether/EtOAc, 95:5) to afford the desired product which is used directly for the next reaction step.

Provenance & Evidence