Potassium tert-butoxide → HCID 66958729, compound

Participants

Reaction Steps

Potassium tert-butoxide (110 mL of a 1 M solution in THF) was added to a solution of tert-butyl 3-[7-bromo-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propylcarbamate (41.63 g, 91.74 mmol) in THF (400 mL). The reaction was stirred for ten minutes at ambient temperature and concentrated under reduced pressure to provide tert-butyl 3-bromo-11,12-dihydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinoline-9(10H)-carboxylate in a crude mixture which was used without purification in Part E.

Provenance & Evidence