Potassium tert-butoxide → tert-butyl 3-bromo-10,11-dihydropyrazino [1',2':1,2]imidazo[4,5-c]quinohne-9(8H)-carboxylate

Participants

Reaction Steps

The method described in Part D of Example 365 was used to treat tert-butyl 2-[7-bromo-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate (10.0 g, 22.7 mmol) with potassium tert-butoxide (27.29 mL of a 1 M solution in THF) with the modification that the reaction was stirred overnight to provide tert-butyl 3-bromo-10,11-dihydropyrazino [1′,2′:1,2]imidazo[4,5-c]quinohne-9(8H)-carboxylate in a crude mixture.

Provenance & Evidence