HCID 66958142, compound → Tert-butyl 3-[(3-amino-7-benzyloxy-quinolin-4-yl)amino]propylcarbamate

Participants

Reaction Steps

tert-Butyl 3-[(7-benzyloxy-3-nitroquinolin-4-yl)amino]propylcarbamate (60.0 g, 132.6 mmol) was dissolved in ethyl acetate (400 mL) and transferred to a Parr hydrogenation vessel charged with 5% platinum on carbon (15.6 g, 80 mmol, 0.03 eq). The vessel was purged with nitrogen gas and placed under hydrogen pressure (50 psi, 3.45×105 Pa) overnight. The catalyst was removed by filtration through a layer of CELITE filter aid, and the filter cake was rinsed with methanol and dichloromethane. The filtrate was concentrated under reduced pressure to provide 52.4 g of tert-butyl 3-[(3-amino-7-benzyloxy-quinolin-4-yl)amino]propylcarbamate.

Provenance & Evidence