Hydrochloric Acid → HCID 66958553, compound

Participants

Reaction Steps

Hydrogen chloride (20 mL of 4 N in 1,4-dioxane) was added to a solution of tert-butyl 6-amino-3-benzyloxy-11,12-dihydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinolin-9(10H)-carboxylate (3.89 g, 8.46 mmol, prepared as described in Part A of Examples 435-450) in dichloromethane (50 mL), and the reaction was stirred at ambient temperature for one hour. Diethyl ether was added, and a precipitate formed. The precipitate was isolated by filtration and dried in a vacuum oven at 65° C. to provide 3.52 g of 3-benzyloxy-9,10,11,12-tetrahydro-8H-[1,4]diazepino[1′,2′:1,2]imidazo[4,5-c]quinolin-6-amine dihydrochloride.

Provenance & Evidence