Bromine → HCID 66932685, compound

HRID 1364082Notes

Reaction equation

HRID 1364082 reaction equation
[CH:1]([CH:4]1[CH2:9][C:8](=[O:10])[CH2:7][C:6](=[O:11])[CH2:5]1)([CH3:3])[CH3:2].[Br:12]Br>CC(O)=O>[Br:12][CH:7]1[C:6](=[O:11])[CH2:5][CH:4]([CH:1]([CH3:3])[CH3:2])[CH2:9][C:8]1=[O:10]

Participants

4

Reactant 2

HCID 24408BromineHCID 5661065-(Isopropyl)cyclohexane-1,3-dione

Product 1

HCID 66932685HCID 66932685, compoundYield 96.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a stirred solution of 5-isopropylcyclohexane-1,3-dione (2 g, 12.9 mmol) in AcOH (20 mL) at r.t. was added bromine (2.06 g, 0.66 mL, 12.9 mmol) dropwise. The reaction was then carried out according to Method A to give the title compound (2.91 g, 96%) as a white solid. δH (DMSO-d6) 2.55-2.48 (4H, m), 2.38-2.32 (1H, m), 1.91-1.82 (1H, m), 1.79-1.54 (1H, m), 0.87 (6H, d, J 6.7 Hz). LCMS (ES+) 234.9 (M+H)+.

Sources & evidence

ORD record
ord-d2928df36a344256b63b01492122e784
Source dataset
uspto-grants-2011_02
Patent number
US07888344B2

Reaction notes

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