反应详情

1,1-Dimethylethyl 2-(4-cyanophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate (may be prepared as described in Description 10) (150 mg, 0.443 mmol) was dissolved in 1,4-dioxan (ml) and 4M hydrogen chloride in 1,4-dioxan (3 ml) added. The mixture was stirred at room temperature for 2 hours. Methanol was added and the mixture purified on 10 g SCX column, eluting initially with methanol, than with 2M ammonia in methanol. Evaporation of the basic fractions gave the title compound (D11). MS (ES+) m/e 239 [M+H]+

1. customthe mixture purified on 10 g SCX column
2. washeluting initially with methanol, than with 2M ammonia in methanol
3. customEvaporation of the basic fractions