Hydrochloric Acid → 4-[6-{[(1,1-dimethylethyl)oxy]carbonyl}-5,6,7,8-tetrahydropyrazolo[3,4-d]azepin-2(4H)-yl]benzoic acid

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Reaction Steps

To 1,1-dimethylethyl 2-(4-cyanophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate (may be prepared as described in Description 10) (750 mg, 2.22 mmol) in ethanol (7.5 ml) was added 10% sodium hydroxide solution (7.5 ml), and the reaction heated at reflux, under argon, for 5 hours. 10% sodium hydroxide solution (10 ml) was added and stirring continued at reflux, under argon, overnight. The reaction was cooled to room temperature and the solvent partially reduced in vacuo. The resulting crude product was dissolved in water and acidified with 5N hydrochloric acid. Ethyl acetate was added, and the product extracted into ethyl acetate (×3). The combined organic fractions were dried over magnesium sulphate and solvent evaporated in vacuo to afford the title compound (D23). MS (ES−) m/e 356 [M−H]−.

Provenance & Evidence