HCID 66930860, compound → HCID 66930857, compound

HRID 1364136Notes

Reaction equation

HRID 1364136 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:17]=[C:16]3[C:10]([CH2:11][CH2:12][N:13](CC4C=CC=CC=4)[CH2:14][CH2:15]3)=[N:9]2)=[CH:4][CH:3]=1>C(O)C.[Pd]>[C:5]1([N:8]2[CH:17]=[C:16]3[C:10]([CH2:11][CH2:12][NH:13][CH2:14][CH2:15]3)=[N:9]2)[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 66930860HCID 66930860, compound

Product 1

HCID 66930857HCID 66930857, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2-(4-bromophenyl)-6-(phenylmethyl)-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine (may be prepared as described in Description 14) (49 mg, 0.13 mmol) in ethanol (5 ml) with palladium (10% Pd/C Paste) as a catalyst (10 mg) was stirred under an atmosphere of hydrogen overnight. The next day, the resulting mixture was filtered through celite and to afford the title compound which may be used without further purification (D46). MS (ES+) m/e 214 [M+H]+

Workup

  1. filtrationThe next day, the resulting mixture was filtered through celite

Sources & evidence

ORD record
ord-a9d5a7c5a02a4ddaa225c4dcae09d02e
Source dataset
uspto-grants-2011_02
Patent number
US07888347B2

Reaction notes

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