Triethylamine → HCID 66930855, compound

Participants

Reaction Steps

A mixture of 1,1-dimethylethyl 2-[1-(phenylmethyl)-4-piperidinyl]-3-{[(trifluoromethyl)sulfonyl]oxy}-3,3a,4,5,7,8-hexahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate (may be prepared as described in Description 48) (355 mg, 0.64 mmol) in ethyl acetate (9 ml) and methanol (3 ml) was treated with triethylamine (0.443 ml, 3.18 mmol) and then Pd(OH)2/C (20% w/w, 70 mg) and the resulting mixture stirred under an atmosphere of H2 for 18.5 h. The mixture was then filtered through kieselguhr and reduced under vacuum. Purification by Mass Directed Autopreparation afforded the title compound (D49). MS (ES+) m/e 321 [M+H]+.

Provenance & Evidence