N,N'-Dimethylethylenediamine → HCID 16048916, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-bromophenyl)-6-cyclobutyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine (may be prepared as described in Example 35) (42 mg, 0.12 mmol), 2-oxazolidinone (21 mg, 0.24 mmol), potassium carbonate (50 mg, 0.36 mmol), copper (I) iodide (8.0 mg, 0.04 mmol) and N,N′-dimethyl-1,2-ethanediamine (5 μl, 0.04 mmol) in dioxane (1.5 ml) was heated in the microwave (high absorption) at 100° C. for 30 minutes. The same amounts again of 2-oxazolidinone, potassium carbonate, copper (I) iodide and N,N′-dimethyl-1,2-ethanediamine were added and the mixture heated in the microwave at 150° C. for 4 hours. The reaction mixture was evaporated in vacuo, then purified by SCX cartridge, followed by Mass Directed Autopreparation to afford the title compound (E37). MS (ES+) m/e 353 [M+H]+.

Provenance & Evidence