N,N'-Dimethylethylenediamine → HCID 16048984, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-bromophenyl)-6-cyclobutyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine (may be prepared as described in Example 35) (80 mg, 0.23 mmol), 1-methylhydantoin (52 mg, 0.46 mmol), potassium carbonate (95 mg, 0.7 mmol), copper (I) iodide (13 mg, 0.07 mmol) and N,N′-dimethyl-1,2-ethanediamine (8 μl, 0.07 mmol) in dioxane (2 ml) was heated in the microwave (normal absorption) at 150° C. for 2 hours. The reaction mixture was purified by SCX cartridge, followed by Mass Directed Autopreparation and column chromatography on silica gel, eluting with a mixture of 2M ammonia in methanol/dichloromethane (0-5%) to afford the title compound (E38). MS (ES+) m/e 380 [M+H]+.

Provenance & Evidence