Cyclobutanone → HCID 16048986, compound

Participants

Reaction Steps

To a solution of 2-[4-(1-piperidinyl)phenyl]-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine (may be prepared as described in Description 43) (42 mg, 0.14 mmol) in dichloromethane (4 ml) was added cyclobutanone (30 μl, 0.42 mmol) followed by acetic acid (3 drops). The mixture was stirred at room temperature for 50 min, then treated with sodium triacetoxyborohydride (89 mg, 0.42 mmol). The mixture was stirred at room temperature for 2.5 hours, then it was diluted with methanol and purified by SCX cartridge to afford the title compound (E40). MS (ES+) m/e 351 [M+H]+.

Provenance & Evidence