Hydrochloric Acid → HCID 377726, compound

Participants

Reaction Steps

To (R)-2-Benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester (1.450 g, 3.95 mmol) in tetrahydrofuran/water (2/1) is added lithium hydroxide (250 mg, 5.92 mmol). After stirred at rt during 16 h, the solution is treated with ethyl acetate and the pH is decrease to 2 with aqueous 1N HCl. The organic phase is dried and evaporated to yield the title compound.

Provenance & Evidence