2-Propanethiol → HCID 58801857, compound

Participants

Reaction Steps

To benzyl bromoacetate (100 mg, 0.437 mmol) in dimethyl formamide (2 mL) is added triethylamine (67 uL, 0.481 mmol) and 2-propanethiol (41 uL, 0.437 mmol). After stirring at rt during 2 h, the solvent is evaporated, the residue is treated with dichloromethane and water. The organic phase is dried and evaporated to give a crude compound before purification by preparative HPLC (Column Waters C18 ODB 5 μm 19×50, Gradient: 0-2.5 min 5% ACN, 2.5-12.5 min 5-100% ACN, 12.5-15 min 100% ACN) to yield the title compound.

Provenance & Evidence