Dimethylformamide → HCID 66939757, compound

Participants

Reaction Conditions

Reaction Steps

To methylhydantoine (50 mg, 0.438 mmol) in DMF (2 mL) is added at 0° C. sodium hydride (23 mg, 0.525 mmol). After stirring at 0° C. during 1 h, methyl 2-bromomethylphenylcarboxylate (121 mg, 0.525 mmol) is added and the mixture is stirred at rt during 2 h before quenching with an aqueous saturated NaHCO3 solution and DCM. The organic phase is dried and evaporated to give a crude compound before purification by preparative HPLC (Column Waters C18 ODB 5 μm 19×50, Gradient: 0-2.5 min 5% ACN, 2.5-12.5 min 5-100% ACN, 12.5-15 min 100% ACN) to yield the title compound.

Provenance & Evidence