HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine → HCID 66940228, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 66940025 | HCID 66940025 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66940228 | HCID 66940228 | — |
Reaction Steps
To 3-Carboxymethylsulfanyl-propionic acid benzyl ester (763 mg, 3 mmol), HBTU (1.71 g, 4.5 mmol) and DIPEA (2.05 mL, 12 mmol) in DCM (10 mL) is added thiomorpholine (283 uL, 3 mmol). After stirring at rt during 2 h and evaporation of the solvent, the residue is dissolved with ethylacetate and washed with an aqueous 1N HCl solution and an aqueous saturated NaHCO3 solution. The organic phase is dried and evaporated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07888351B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-6486d36a62464727b150ec9065e207a1 |
| Source note | uspto-grants-2011_02 |