HCID 63900315, compound → 2-morpholin-4-ylsulfonylacetic acid

HRID 1364185Notes

Reaction equation

HRID 1364185 reaction equation
C[O:2][C:3](=[O:14])[CH2:4][S:5]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)(=[O:7])=[O:6]>C1CCCCC1.C(OCC)(=O)C>[N:8]1([S:5]([CH2:4][C:3]([OH:14])=[O:2])(=[O:7])=[O:6])[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1

Participants

3

Reactant 1

HCID 63900315HCID 63900315, compound

Product 1

HCID 3325172-morpholin-4-ylsulfonylacetic acid

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

(Morpholine-4-sulfonyl)acetic acid methyl ester (0.5 g, 2.24 mmol) is dissolved in 0.66 N KOH aqueous ethanol solution (1/1, 150 mL) and the mixture is heated at reflux during 16 h. The solvent is evaporated and residue is extracted with dichloromethane/methanol 4:1 to yield the title compound.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux during 16 h
  3. customThe solvent is evaporated
  4. extractionresidue is extracted with dichloromethane/methanol 4:1

Sources & evidence

ORD record
ord-117390f3f3914bee9b79964ddae75a0b
Source dataset
uspto-grants-2011_02
Patent number
US07888351B2

Reaction notes

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