3-Mercaptopropionic Acid → HCID 24693400, compound

Participants

Reaction Conditions

Reaction Steps

To 3-mercaptopropionic acid (200 mg, 1.884 mmol) in methanol (3 mL) are added sodium methoxide (204 mg, 3.768 mmol) and 2-Bromo-N,N-diethyl-acetamide (402 mg, 2.070 mmol). After stirring at 80° C. during 4 h and evaporation of solvent, the residue is treated with ethyl acetate and water, the pH is adjusted to 10 with an aqueous NaHCO3 solution and the aqueous phase is extracted with ethyl acetate. After acidification of the aqueous phase to pH 2 with an aqueous 1N HCl solution, it is extracted with ethyl acetate, then the organic phase is dried and evaporated to give the title compound.

Provenance & Evidence