Dichlorodimethylsilane → 7-Mercapto-3,4-dihydro-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	Dichlorodimethylsilane	HCID 6398	—
Reactant	1,3-Dimethyl-2-imidazolidinone	HCID 6661	—
Reactant	1-Oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride	HCID 18071374	—
Catalyst	Zinc	HCID 23994	—
Solvent	1,2-Dichloroethane	HCID 11	—
Product	7-Mercapto-3,4-dihydro-2H-isoquinolin-1-one	HCID 64225426	—

Reaction Steps

To a zinc powder (2.79 g, 42.7 mmol) and Dichlorodimethylsilane (5.15 mL, 42.7 mmol) in DCE (45 mL) is added a solution of 1-Oxo-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride (3 g, 12.2 mmol) and 1,3-dimethylimidazolidin-2-one (3.96 mL, 36.6 mmol) in DCE (5 mL). After stirring at rt during 2 h, the mixture is concentrated.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07888351B2
Source dataset	uspto-grants-2011_02
ORD ID	ord-0333231d9de44f7b930d83cd99972a19
Source note	uspto-grants-2011_02