Tetrahydrofuran → HCID 23661730, compound

Participants

Reaction Steps

A mixture of the crude product described above (1.01 g), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (0.843 g, 4.39 mmol), 1-hydroxybenzotriazole (0.593 g, 4.39 mmol), diisopropylethylamine (1.90 mL, 11.0 mmol), the product from Step 3 (0.843 g, 2.42 mmol) and tetrahydrofuran (15 mL) was stirred for 18 hours at room temperature. The reaction was then diluted with H2O and extracted with ethyl acetate. The organic extracts were concentrated in vacuo and purified via flash chromatography on silica gel (0% to 50% ethyl acetate/hexanes linear gradient) to give the desired product.

Provenance & Evidence