N-(2-allyl-4-fluoro-phenyl)-acrylamide → HCID 57779786, compound

HRID 1364200Notes

Reaction equation

HRID 1364200 reaction equation
[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[NH:11][C:12](=[O:15])[CH:13]=[CH2:14])C=C>ClCCl>[F:10][C:8]1[CH:7]=[CH:6][C:5]2[NH:11][C:12](=[O:15])[CH:13]=[CH:14][CH2:1][C:4]=2[CH:9]=1

Participants

3

Reactant 1

HCID 57779791N-(2-allyl-4-fluoro-phenyl)-acrylamide

Product 1

HCID 57779786HCID 57779786, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A round-bottom flask containing the product from Step 2 (4.51 g, 21.9 mmol) was fitted with a stirbar and septa. Dichloromethane (800 mL) and Zhan catalyst I (0.735 g, 1.11 mmol) were added, and the resulting solution was stirred for 18 hours at room temperature. The reaction was then concentrated in vacuo and recrystallized from dichloromethane to give the desired product.

Workup

  1. customwas fitted with a stirbar and septa
  2. concentrationThe reaction was then concentrated in vacuo
  3. customrecrystallized from dichloromethane

Sources & evidence

ORD record
ord-3acdda58df154d9586e72789305e7edf
Source dataset
uspto-grants-2011_02
Patent number
US07888345B2

Reaction notes

Loading…