1-Bromo-4-chlorobutane → HCID 66885306, compound

HRID 1364255Notes

Reaction equation

HRID 1364255 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([CH3:13])[C:9]2=[O:12])=[CH:4][CH:3]=1.Br[CH2:15][CH2:16][CH2:17][CH2:18][Cl:19]>>[Cl:19][CH2:18][CH2:17][CH2:16][CH2:15][O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([CH3:13])[C:9]2=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 813641-Bromo-4-chlorobutaneHCID 66885381HCID 66885381, compound

Product 1

HCID 66885306HCID 66885306, compound

Procedure

By a similar method as in Reference Example 9,7-(4-chlorobutoxy)-2-methyl-3,4-dihydro-2H-isoquinolin-1-one in the form of a brown oil was prepared from 7-hydroxy-2-methyl-3,4-dihydro-2H-isoquinolin-1-one using 1-bromo-4-chlorobutane.

Sources & evidence

ORD record
ord-3045ee29cef94d5ba3895e0961c88dac
Source dataset
uspto-grants-2011_02
Patent number
US07888362B2

Reaction notes

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